Article ID Journal Published Year Pages File Type
6174298 European Journal of Obstetrics & Gynecology and Reproductive Biology 2012 5 Pages PDF
Abstract
The reduced activity of the 11β-HSD2 gene seen in the preterm delivery group may impair fetal defences against maternal glucocorticoid exposure. In cases of impending premature delivery, glucocorticoid effects, potentially including postnatal neurological abnormalities and growth restriction, may be worsened by prophylactic steroids given to accelerate fetal lung maturity. The impairment in fetal defences against maternal glucocorticoids due to reduced 11β-HSD2 enzyme activity appears to begin after gestational week 28.
Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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