Vascular endothelial growth factor gene polymorphisms in Korean patients with premature ovarian failure

ObjectiveTo study the association of vascular endothelial growth factor (VEGF) polymorphisms (−2578C>A, −1154G>A, −634G>C, and 936C>T) with premature ovarian failure (POF) in Korean patients.Study designProspective case-control study. One hundred and thirty five patients with POF and confirmed serum follicle-stimulating hormone levels of >40 IU/L before the age of 40 years and 120 healthy controls with at least one live birth, regular menstrual cycles, and karyotype 46, XX.ResultsPOF patients exhibited significantly different frequencies of the VEGF −1154GA genotype (odds ratio [OR], 2.002; 95% confidence interval [CI], 1.116-3.592; P = 0.019), and −2578CA+AA/−1154GA+AA combination genotype (OR, 1.805; 95% CI, 1.013-3.217; P = 0.044) compared to the control group. The frequency of the −2578A/−1154A haplotype (OR, 1.647; 95% CI, 1.017-2.677; P = 0.041) was significantly higher in the POF group than in the control group.ConclusionThe VEGF −1154G>A mutation, −2578CA+AA/−1154GA+AA combination genotype, and −2578A/−1154A haplotype are significantly associated with POF in Korean women.