| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6176219 | European Urology | 2015 | 7 Pages |
Abstract
Brief cold stimuli applied to the skin can evoke a sudden desire to urinate, which can be highly bothersome in patients with overactive bladder. We developed an animal model to study this phenomenon, and found that it depends on a specific molecular cold sensor, transient receptor potential M8 (TRPM8). Pharmacological inhibition of TRPM8 may alleviate acute cold-induced urinary urgency in humans.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Obstetrics, Gynecology and Women's Health
Authors
Pieter Uvin, Jan Franken, Silvia Pinto, Roma Rietjens, Luc Grammet, Yves Deruyver, Yeranddy A. Alpizar, Karel Talavera, Rudi Vennekens, Wouter Everaerts, Dirk De Ridder, Thomas Voets,