Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6178580 | Fertility and Sterility | 2016 | 13 Pages |
Abstract
Fetal Met-Met COMT genotype reduces COMT placental expression and activity in vitro and increases preeclampsia, risk but it does not explain the difference in maternal 2-ME levels between preeclamptic and normal pregnancies. However, the preeclamptic patients had elevated homocysteine levels that correlated inversely with 2-ME, indicating that an altered methionine-homocysteine metabolism may contribute to reduce COMT activity in vivo and explain the decreased levels of 2-ME in preeclamptic women.
Related Topics
Health Sciences
Medicine and Dentistry
Obstetrics, Gynecology and Women's Health
Authors
Miriam M.D., Ph.D., Francisco J. M.D., Ph.D., Moisés M.D., Ph.D., Jaime Ph.D., M.P.H., Juan L. M.D., Ph.D., Bárbara Ph.D., Andrés Ph.D., Bernardo Ph.D., Vicente M.D., Ph.D., Isabel M.D., Ph.D.,