Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6179600 | Fertility and Sterility | 2012 | 5 Pages |
Abstract
The adhesion phenotype, which is normally expressed in response to hypoxia, is reproduced in a normoxic environment by uncoupling oxidative phosphorylation with DNP, as evidenced by an increase in type I collagen and VEGF. Acquisition of the adhesion phenotype was via a mechanism distinct from up-regulation of HIF-1α. These observations are consistent with the hypothesis that the adhesion phenotype represents a state of intracellular metabolic depletion.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Obstetrics, Gynecology and Women's Health
Authors
Valerie I. M.D., Nicole M. B.S., Zhong L. M.D., Ph.D., Ghassan M. Ph.D., Michael P. M.D.,