| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6179985 | Fertility and Sterility | 2011 | 5 Pages |
Abstract
The aim of this study was to evaluate the protective effect of calcium folinate (CF) applied in 10% of the methotrexate (MTX) dosage against morphologic and steroid-receptor damage induced by MTX in rat endosalpinx. The result indicated that endosalpingitis, the ultrastructural damage of endosalpinx, and a change in estrogen and P receptor expression induced by low- and high-dose MTX in endosalpinx can be reversed completely and partly (B1, B2) by combined treatment with CF, suggesting that CF combined with MTX protects against the side effects induced by MTX.
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Authors
Xiao-Jun Ph.D, Yan-Ping M.D., Han-Chu M.D., Jing M.D., Fei-Yun M.D.,