| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6181178 | Fertility and Sterility | 2015 | 8 Pages |
Abstract
Leiomyoma-derived TGF-β was necessary and sufficient to alter endometrial BMP-2 responsiveness. Blockade of TGF-β prevents repression of BMP-2 receptors and restores BMP-2-stimulated expression of HOXA10 and LIF. Blockade of TGF signaling is a potential strategy to improve infertility and pregnancy loss associated with uterine leiomyoma.
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Authors
Leo F. M.D., Hugh S. M.D.,