Article ID Journal Published Year Pages File Type
6182535 Fertility and Sterility 2012 11 Pages PDF
Abstract
Elevated leiomyoma miR-21 levels are predicted to decrease PDCD-4 levels, thus leiomyomas differ from other tumors where loss of PDCD-4 is associated with tumor progression. Our studies indicate regulation of PDCD-4 expression is not a primary miR-21 function in leiomyomas, but instead miR-21 is able to impact cellular apoptosis and translation, through unknown targets, in a manner consistent with its involvement in the pathophysiology of uterine fibroids.
Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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