Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6182535 | Fertility and Sterility | 2012 | 11 Pages |
Abstract
Elevated leiomyoma miR-21 levels are predicted to decrease PDCD-4 levels, thus leiomyomas differ from other tumors where loss of PDCD-4 is associated with tumor progression. Our studies indicate regulation of PDCD-4 expression is not a primary miR-21 function in leiomyomas, but instead miR-21 is able to impact cellular apoptosis and translation, through unknown targets, in a manner consistent with its involvement in the pathophysiology of uterine fibroids.
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Authors
J. Browning B.S., Vargheese Ph.D., Faezeh M.S., Romana A. Ph.D., Lane K. Ph.D.,