Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6182678 | Gynecologic Oncology | 2015 | 9 Pages |
Abstract
Ovarian cancer spheroids can be generated from limited cell numbers in high throughput 384 well plates with high viability. Spheroids demonstrate therapeutic resistance relative to cells in traditional 2D culture. Stable incorporation of low cell numbers is advantageous when translating this research to rare patient-derived cells. This system can be used to understand ovarian cancer spheroid biology, as well as carry out preclinical drug sensitivity assays.
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Authors
Shreya Raghavan, Maria R. Ward, Katelyn R. Rowley, Rachel M. Wold, Shuichi Takayama, Ronald J. Buckanovich, Geeta Mehta,