| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6182768 | Gynecologic Oncology | 2014 | 7 Pages |
Abstract
Independent of PIK3CA gene mutation, BKM mediated inhibition of the PI3K/AKT/mTOR pathway in endometrial tumors precludes tumor growth in a primary xenograft model. While a pattern of resistance emerges, this effect appears to be mitigated by the addition of conventional cytotoxic chemotherapy.
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Authors
Leslie S. Bradford, Alejandro Rauh-Hain, Rachel M. Clark, Jolijn W. Groeneweg, Ling Zhang, Darrell Borger, Lawrence R. Zukerberg, Whitfield B. Growdon, Rosemary Foster, Bo R. Rueda,