Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6188342 | Journal of Reproductive Immunology | 2015 | 4 Pages |
Abstract
CD200 expression in murine trophoblast and decidua prevents semi-allogeneic and LPS-induced abortions by binding to CD200 receptor-bearing cells to suppress NK activity, induces IDO in macrophages, and promotes the generation of regulatory T cell subsets. CD200 and its receptor CD200R1 reported in 7-9 weeks' gestation human villus trophoblasts are reduced in spontaneous abortion syncytiotrophoblasts. By specific antibody staining, we find that both CD200 and CD200R1 are expressed even earlier, by 5 weeks' gestation, by villus trophoblasts and by decidual cells. Expression of CD200 was validated using two independent antibodies. CD200-CD200R1 signaling may be required for human pregnancy success.
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Authors
David A. Clark, Jorge L. Arredondo, Sukhbinder Dhesy-Thind,