Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6188562 | Reproductive BioMedicine Online | 2016 | 5 Pages |
Abstract
Exonuclease 1 (EXO1) is required for both DNA repair and meiosis. Inactivation of EXO1 gene in mice leads to infertility. This study aimed to investigate whether variants in the EXO1 gene contribute to human premature ovarian failure (POF). The coding region of EXO1 was sequenced in 186 Han Chinese patients with non-syndromic POF. No plausible mutation was detected. The results suggest that mutations in the coding region of EXO1 may not be responsible for POF in Han Chinese women.
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Authors
Shizhen Su, Ting Han, Bowen Ma, Weiping Li, Yingying Qin, Shidou Zhao, Zi-Jiang Chen,