Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6188675 | Reproductive BioMedicine Online | 2015 | 8 Pages |
Abstract
The aim of this study was to evaluate whether prolongation of the time interval between HCG administration and oocyte retrieval, from 36âh to 38âh, affects oocyte retrieval rate in women undergoing ovarian stimulation with gonadotrophins and GnRH antagonists for IVF. One hundred and fifty-six normo-ovulatory women were randomized to have oocyte retrieval performed 36âh (n = 78) or 38âh (n = 78) following HCG administration. Oocyte retrieval rate was defined as number of cumulus-oocyte-complex (COC) retrieved/follicle â¥11âmm present on day of HCG administration. No significant differences were observed between the groups regarding baseline characteristics. Moreover, no significant difference was observed between the groups regarding oocyte retrieval rate (difference: + 1.2%, 95% CI for difference between medians: â4.5 to +12.1). The median (95% CI for the median) was not significantly different between the groups regarding number of cumulus-oocyte-complexes (COCs) retrieved: 5.5 (5.0-7.0) versus 6.0 (5.0-6.2), respectively, and fertilization rates: 57.7% (50.0-66.7) versus 50.0% (44.8-65.5), respectively. Live birth rates were similar between the groups (20.5% versus 16.7%, RD: + 3.8%, 95% CI: â8.5 to +16.1, respectively). Prolongation of time interval between HCG administration and oocyte retrieval from 36âh to 38âh does not affect oocyte retrieval rate.
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Authors
Julia K. Bosdou, Efstratios M. Kolibianakis, Christos A. Venetis, Leonidas Zepiridis, Katerina Chatzimeletiou, Anastasios Makedos, Stylianos Triantafyllidis, Sevasti Masouridou, Anna Mitsoli, Basil Tarlatzis,