Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6188908 | Reproductive BioMedicine Online | 2014 | 8 Pages |
This study compared the effect on blastocyst development and clinical outcome of coasting in women at increased risk of moderate-severe ovarian hyperstimulation syndrome (OHSS; nâ=â389) with a control group matched for age and basal FSH that did not undergo coasting (nâ=â386) in IVF/intracytoplasmic sperm injection (ICSI) cycles. The main outcome measures were rate of blastocyst development and live birth. More cycles progressed to the blastocyst stage in the coasted group (nâ=â169) compared with the control group (nâ=â83; 43.4% versus 21.5%; Pâ<â0.001). The biochemical pregnancy, clinical pregnancy and live birth rates were similar (46.5% versus 42.0%; 40.6% versus 37.8%; 31.6% versus 30.1%). The duration of coasting up to 4âdays did not affect progression to blastocyst stage. The multivariate model showed that coasting (OR 1.73, Pâ=â0.004) and the number of oocytes retrieved (OR 1.17, Pâ=â0.001) were positively correlated with blastocyst formation. Coasting, a measure to reduce the risk of OHSS, does not impair blastocyst development or clinical outcome. Coasting should remain an effective measure to prevent OHSS.