Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6189043 | Reproductive BioMedicine Online | 2014 | 7 Pages |
Abstract
This retrospective cohort study followed a total of 364 women were followed from their first fresh, donor ICSI cycle for up to six ICSI cycles. All patients started their treatment between January 2003 and December 2007. Live birth delivery after 25Â weeks of gestation was the main outcome measure of our study. All patients without a delivery after 25Â weeks in an ICSI cycle were eligible for a subsequent cycle, including patients with cancelled cycles and those with a pregnancy that did not result in a live birth. The overall expected cumulative delivery rate after six ICSI cycles was 90% (95% confidence interval, CI, 86-94%). In women aged 38-39Â years, the crude and expected cumulative delivery rates after six cycles were 54% (95% CI 43-66%) and 82% (95% CI 67-97%), respectively. In women aged 30-37Â years, the crude and expected cumulative delivery rates after six cycles were 66% (95% CI 60-72%) and 91% (95% CI 86-96%), respectively. In women aged 20-29Â years the crude and expected cumulative delivery rates after six cycles were 81% (95% CI 71-90%) and 93% (95% CI 86-100%), respectively. No significant difference was found between the cumulative delivery rates of patients who had a primary ICSI treatment (no previous intrauterine insemination) and patients who had previous intrauterine insemination. Our study corroborates the impact of age on ICSI with donor spermatozoa.
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Authors
Michaël De Brucker, Michel Camus, Patrick Haentjens, Jacques Francotte, Greta Verheyen, Herman Tournaye,