Article ID Journal Published Year Pages File Type
6189148 Reproductive BioMedicine Online 2013 7 Pages PDF
Abstract

Early mammalian development consists of two distinct phases separated by the event of implantation. Whereas much has been discovered about developmental mechanisms prior to implantation, the inability to culture and follow in real time cell behaviour over the period of implantation means that the second phase has not been explored in as much detail. Recently, a novel in-vitro culture system was described that permits continuous culture and time-lapse observations through the peri- and early post-implantation stages. This system has already delivered detailed information on the cellular processes accompanying early morphogenesis and allowed direct connections to be established between events occurring at the two developmental phases. This review discusses the potential of this novel technology and its possible applications that could have not only impact on basic science but also practical implications for human medicine.Early mammalian development consists of two distinct phases separated by the event of implantation (preimplantation and post-implantation). Whereas much has been discovered about developmental mechanisms prior to implantation, the inability to culture and follow in real time cell behaviour over the period of implantation has resulted in the second phase remaining explored in much less detail. Recently, a novel in-vitro culture system was described that permits continuous culture and time-lapse observations through the peri- and early post-implantation stages. This system has already delivered detailed information on the cellular processes accompanying early morphogenesis and allowed direct connections to be established between events occurring at the two developmental phases. This review discusses the potential of this novel technology and its possible applications that could have not only impact on basic science but also practical implications for human medicine.

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Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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