Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6189276 | Seminars in Fetal and Neonatal Medicine | 2011 | 5 Pages |
Abstract
SummaryChromosome imbalances are the leading cause of intellectual and developmental disabilities in the population. This paper reviews the current methods used to diagnose chromosome abnormalities in children including karyotyping, fluorescence in situ hybridization and microarray technologies. Advances in molecular cytogenetics, especially with the use of microarrays, have substantially increased the detection of chromosome abnormalities in children with disabilities and congenital anomalies above that achievable with conventional cytogenetic banding and light microscopy.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Obstetrics, Gynecology and Women's Health
Authors
Lisa G. Shaffer, Bassem A. Bejjani,