Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6190446 | Cancer Treatment Reviews | 2015 | 9 Pages |
Abstract
Despite these disappointments, there is reason for optimism. Our improved understanding of key signal transduction pathways and of tumour specific DNA repair deficiencies has produced new opportunities to specifically radiosensitise tumours. Novel strategies to reduce tumour hypoxia include the use of drugs that cause vascular normalisation and drugs that reduce tumour oxygen consumption. These new strategies, combined with better compounds at our disposal, and an ability to learn from our previous mistakes, mean that there is great promise for future drug-radiotherapy combinations to result in significant clinical benefits.
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Authors
Geoff S. Higgins, Sean M. O'Cathail, Ruth J. Muschel, W. Gillies McKenna,