Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6190747 | Clinical Radiology | 2015 | 7 Pages |
â¢Spectral CT detected the change of IC of gastric carcinomas to NC.â¢The change of IC had correlation with pathological regression grades.â¢The response prediction efficacy of IC was better than tumor size.â¢The response prediction ability of IC on arterial phase was superior to venous phase.
AimTo investigate the potential of iodine concentration (IC) determined using virtual monochromatic spectral computed tomography (CT) to predict the response of gastric carcinomas to preoperative neoadjuvant chemotherapy (NC).Materials and methodsA total of 20 patients were enrolled who underwent two spectral CT examinations (1 week before and two cycles after NC). The percentage change in tumour thickness (%ÎCWT) and in IC on the arterial phase (%ÎIC-a) and venous phase (%ÎIC-v) after NC were calculated and compared for different histopathological regression grades and response groups. The diagnostic efficacies to discriminate good response (GR) and poor response (PR) of the above three parameters were evaluated using receiver operating characteristic (ROC) curves.ResultsThe decrease rate of %ÎIC-a for the GR group was higher than that for the PR group (â0.59 [â0.76, â0.20] versus â0.11 [â0.75, 0.92], p=0.012). There was no significant difference in the %ÎIC-v and %ÎCWT values between the GR and PR groups (p=0.076 and p=0.779, respectively). The areas under the ROC curve (AUC) values were 0.857, 0.762, and 0.542 for %ÎIC-a, %ÎIC-v, and %ÎCWT, respectively, in the response prediction. The cut-off value for identifying PR was a decrease rate of <52.9% for %ÎIC-a, and the sensitivity and specificity values were 0.857 and 0.833.ConclusionChanges in the IC for gastric carcinomas following NC were detected using spectral CT and correlated with histopathological regression. The prediction efficacy for IC was better than that for tumour thickness, with IC on the arterial phase being a better predictor than IC on the venous phase.