Efficacy of fiducial marker-based image-guided radiation therapy in prostate tomotherapy and potential dose coverage improvement using a patient positioning optimization method

Given the planning target volume margin size specified in the current study, the fiducial marker-based IGRT approach may not be completely adequate to achieve desired dose coverage of the target volumes at every fraction. Due to relatively poor image quality of MVCTs, additional investigations may be required to confirm the finding. The proposed positioning correction optimization method is shown to effectively improve the observed suboptimal dose coverage of the target volumes.