Enhanced Benefit in Diabetic Macular Edema from AKB-9778 Tie2 Activation Combined with Vascular Endothelial Growth Factor Suppression

Article ID	Journal	Published Year	Pages	File Type
6198958	Ophthalmology	2016	9 Pages	PDF

Abstract

Activation of Tie2 by subcutaneous injections of AKB-9778 combined with suppression of vascular endothelial growth factor (VEGF) causes a significantly greater reduction in DME than that seen with suppression of VEGF alone.

Keywords

twice per day SD OCT DME DRSS ETDRS BCVA TIE2 CSt Diabetic macular edema best-corrected visual acuity Spectral-domain optical coherence tomography early treatment diabetic retinopathy study central subfield thickness adverse event Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)Nitric oxide BID

Related Topics

Health Sciences Medicine and Dentistry Ophthalmology

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Enhanced Benefit in Diabetic Macular Edema from AKB-9778 Tie2 Activation Combined with Vascular Endothelial Growth Factor Suppression

Authors

Peter A. MD, Arshad MD, Michael MD, Sunil MD, David MD, Pravin MD, Saleema MD, Barbara PhD, Laura BS, Kevin MD, Mitchell PhD, TIME-2 Study Group TIME-2 Study Group,