Aggregate Effects of Intraocular Pressure and Cup-to-Disc Ratio Genetic Variants on Glaucoma in a Multiethnic Asian Population

Article ID	Journal	Published Year	Pages	File Type
6200631	Ophthalmology	2015	9 Pages	PDF

Abstract

Higher IOP-, VCDR-specific GRSs were associated with greater risk of glaucoma. Participants with both GRSs in the top tertiles had a 5.5-fold increased risk of glaucoma compared with those in the bottom tertiles. These findings may provide insights into the genetic pathogenesis of glaucoma.

Keywords

VCDR PACG POAG GRs iOp AUC Seed confidence interval Intraocular pressure area under the curve principal component odds ratio vertical cup-to-disc ratio genetic risk score Single nucleotide polymorphism SNP quality control primary angle-closure glaucoma primary open-angle glaucoma

Related Topics

Health Sciences Medicine and Dentistry Ophthalmology

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Aggregate Effects of Intraocular Pressure and Cup-to-Disc Ratio Genetic Variants on Glaucoma in a Multiethnic Asian Population

Authors

Yih-Chung BSc (Hons), Jiemin MSc, Eranga N. PhD, Chiea-Chuen MBBS, PhD, Yik-Ying PhD, E-Shyong FRCP, PhD, Tien Y. FRCS, PhD, Tin FRCS (Ed), PhD, Ching-Yu MD, PhD, International Glaucoma Genetics Consortium International Glaucoma Genetics Consortium,