| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6200829 | Ophthalmology | 2016 | 7 Pages |
Abstract
This longitudinal study corroborates our previous cross-sectional study finding that higher levels of unbound α-crystallin as assessed by ACI are associated with lower risk of cataract formation and that loss of ACI over time is associated with cataract formation and progression. This study suggested that assessment of ACI with the DLS device could be used as a surrogate for lens opacity risk in clinical studies, and for assessing nuclear cataract events in studies where cataract development may be a side effect of a drug or device.
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Authors
Manuel B. MD, Rafat R. PhD, Junko MD, PhD, Holly COA, Andrea I. MD, Jing PhD, Susan PhD, J. Samuel PhD, Frederick L. MD, Sheila K. PhD, Walter J. MD,