| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 620343 | Chemical Engineering Research and Design | 2016 | 7 Pages |
•The effect of β-CD, SLS and PEG on the solubilization of Lamotrigine was studied.•Applications of all solubilizing agents lead to an improvement in drug solubility.•Micellization and complexation show synergistic effect on drug solubility.•Experimental solubility data were fitted to Jouyban-Acree model.•Excellent agreement was obtained between experimental and calculated data.
The present work was carried out with the purpose of evaluating the effect of β-cyclodextrin (β-CD), sodium lauryl sulfate (SLS) and polyethylene glycol 200 (PEG 200) on the solubilization of lamotrigine by means of phase-solublility studies and solubility prediction using Jouyban-Acree model.The experimental solubility values of various mixtures were fitted to the equation and fitting accuracy of solubility data to this model was evaluated. A quantitative relationship between the solubilizing agents was assessed and the predictive accuracy of the Jouyban-Acree model and its applicability assuring reliable prediction of the model in binary systems was studied. The significance of the simultaneous presence of SLS and β-CD on lamotrigine solubility was studied in binary solvent mixture.
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