Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6213561 | International Journal of Pediatric Otorhinolaryngology | 2013 | 5 Pages |
Abstract
Jacobsen syndrome is an uncommon but well-known contiguous gene syndrome caused by partial deletion involving the long arm of chromosome 11. Most common features include: psychomotor impairment, facial dysmorphism, and thrombocytopenia. Cleft palate has been rarely reported.A case of Jacobsen syndrome confirmed by cytogenomic analysis is presented with review of the literature. Main clinical features were phonological disorder, submucous cleft palate (SMCP) and velopharyngeal insufficiency (VPI). VPI was corrected surgically according to findings of videonasopharyngoscopy and videofluoroscopy.It is concluded that clinicians should consider that VPI associated with SMCP may be the main manifestations of a chromosomal syndrome.
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Authors
Antonio Ysunza, Kenneth Shaheen, David J. Aughton, Mark A. Micale, Richard Merson, Kris Rutkowski,