Predictive Value of Adenosine 5′-Monophosphate Challenge in Preschool Children for the Diagnosis of Asthma 5 Years Later

We evaluated the predictive values of preschool bronchial challenge with nebulized adenosine 5′-monophosphate (AMP) using the auscultation method for having asthma 5 years later. Preschool AMP challenge had a high negative (90%) and a moderate positive (67%) predictive value for asthma 5 years later. Positive predictive value increased with the age at which the challenge was performed. The degree of preschool response to AMP was associated with the severity of asthma at school age.