| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6227309 | Biological Psychiatry | 2014 | 10 Pages |
Abstract
We validate a new preclinical paradigm to examine cellular mechanisms underlying the antidepressant-like activity of vmPFC DBS and identify dramatic circuit-mediated cellular adaptations that coincide with this treatment. These neuroplastic changes of 5-HT neurons might contribute to the progressive mood improvements reported in patients treated with chronic courses of cortical DBS.
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Authors
Avin Veerakumar, Collin Challis, Preetika Gupta, Jennifer Da, Aseem Upadhyay, Sheryl G. Beck, Olivier Berton,