Article ID Journal Published Year Pages File Type
6231235 Journal of Affective Disorders 2015 62 Pages PDF
Abstract
Cellular modeling has proven useful in BD, and potential pathways, especially in cellular resilience related mechanisms have been identified. These findings show consistency with other study designs (genome-wide association, brain-imaging, and post-mortem brain expression). ONE cells and IPSC reprogrammed neurons represent the next generation of cell models in BD. Future studies should focus on family-based study designs and combine cell models with deep sequencing and genetic manipulations.
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Health Sciences Medicine and Dentistry Psychiatry and Mental Health
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