Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6231235 | Journal of Affective Disorders | 2015 | 62 Pages |
Abstract
Cellular modeling has proven useful in BD, and potential pathways, especially in cellular resilience related mechanisms have been identified. These findings show consistency with other study designs (genome-wide association, brain-imaging, and post-mortem brain expression). ONE cells and IPSC reprogrammed neurons represent the next generation of cell models in BD. Future studies should focus on family-based study designs and combine cell models with deep sequencing and genetic manipulations.
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Authors
Biju Viswanath, Sam P. Jose, Alessio Squassina, Jagadisha Thirthalli, Meera Purushottam, Odity Mukherjee, Vladimir Vladimirov, George P. Patrinos, Maria Del Zompo, Sanjeev Jain,