Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6231359 | Journal of Affective Disorders | 2015 | 7 Pages |
â¢Cellular and humoral immune changes may underlie seasonal affective disorder (SAD).â¢We presently investigated these changes as well as the effect of light therapy in SAD patients.â¢In SAD patients, enhanced inflammatory response occurred in winter compared to summer.â¢Patients had higher macrophage activity and lower lymphocyte proliferation in winter.â¢Macrophage-produced IL-1β, TNF-α and Th-1 produced IFN-γ were all increased.â¢Light therapy improved depressive scores and balanced above SAD related immune-changes.
BackgroundAnimals show seasonal changes in the endocrine and immune system in response to winter stressors. Even though increased inflammation has been implicated in the pathophysiology of depression, whether immune disorder is a key mediator in seasonal affective depression (SAD) is unknown. Here, we hypothesized that short photoperiods in winter may induce inflammatory response, which contributes to SAD, and that light treatments should normalize immune function and improve depressive symptoms.MethodsTwenty patients with a diagnosis of SAD, and a score on the HAM-29 of 20 or higher were recruited for this study. Twenty-one healthy subjects with no personal and family history of psychiatric disorder were matched to patients according to age and sex. Patients and controls were sampled during winter between November and January, inclusive. A subset of SAD patients (N=13) was re-sampled after 4 weeks of light therapy. Blood samples were assayed for macrophage activity, lymphocyte proliferation and cytokine release.ResultsSAD patients showed significantly higher macrophage activity and lower lymphocyte proliferation in winter compared to healthy subjects. The concentrations of macrophage-produced proinflammatory cytokines interleukin-1β and tumour necrosis factor-α, and T-helper (Th)-1 produced cytokine, interferon-γ were all significantly increased. In contrast, no significant changes in Th2-produced cytokines were observed. Light therapy significantly improved depressive scores, which was associated with attenuation of decreased lymphocyte functions, increased macrophage activity and level of proinflammatory cytokines.ConclusionSAD patients have increased macrophage and Th1 type responses in winter, and light therapy normalized immune functions and depressive symptoms. These results support an inflammatory hypothesis for SAD and an immunomodulatory role of light therapy.