Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6233058 | Journal of Affective Disorders | 2014 | 7 Pages |
Abstract
Our findings indicate that the HAM-D6 and IDS-C6 melancholia scales capture a coherent construct in depression. The syndrome reflected in these scales is unidimensional, sensitive to specific pharmacological intervention, and therefore likely to have biological validity. We therefore believe that “melancholia” thus defined could be a valuable construct under the Research Domain Criteria (RDoC), which specifically aims at identifying the neurobiology underlying mental disorders and providing drugable targets.
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Authors
Søren D. Ãstergaard, Per Bech, Madhukar H. Trivedi, Stephen R. Wisniewski, A. John Rush, Maurizio Fava,