Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
62337 | Journal of Catalysis | 2008 | 7 Pages |
Abstract
A continuous-flow two-step process for the production of multifunctional intermediate compounds was performed with a combination of two column reactors packed with different organic immobilized catalysts. The first step of the reaction, nitroaldol condensation between aromatic aldehydes and nitromethane, is promoted by a silica gel-supported primary amine; the second step, Michael addition of β-dicarbonyl compounds to the nitrostyrenes obtained in the first step, is catalyzed by a silica gel-supported guanidine TBD. In both cases, the catalysts can be directly reused for several runs with no significant changes in activity.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Catalysis
Authors
L. Soldi, W. Ferstl, S. Loebbecke, R. Maggi, C. Malmassari, G. Sartori, S. Yada,