Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6241200 | Respiratory Medicine | 2016 | 14 Pages |
Abstract
It is likely that, at least in some categories of asthmatics, an increased cholinergic tone, rather than other well-known factors, might play a prevalent role in triggering bronchospasm. If this is the case, it is possible to speculate that the use of anticholinergic agents (mainly those with long-acting activity) in patients suffering from asthma should be more beneficial in individuals characterized by a higher degree of cholinergic tone that, consequently might be the ideal target for the use of long-acting anticholinergics and, possibly, represent a novel asthma phenotype. The presence of parasympathetic-associated n-RSs might help the physician to identify this type of patients, although this might be followed by a more detailed assessment.
Keywords
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Authors
Gennaro Liccardi, Antonello Salzillo, Luigino Calzetta, Mario Cazzola, Maria Gabriella Matera, Paola Rogliani,