| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6242074 | Respiratory Medicine | 2011 | 6 Pages |
Abstract
The effects of SYM100 and SYM200 on GR activation were not different from that of BUD800 and superior to BUD200. Thus, it has been confirmed at a molecular level that inhaled combination therapy with a lower dose of budesonide has an equivalent effect to a high dose of budesonide alone. In addition, GR-GRE binding is found to be a valuable pharmacodynamic marker for steroid efficacy in clinical studies. (Registration No. NCT00159263)
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Authors
Sarah Essilfie-Quaye, Kazuhiro Ito, Misako Ito, Sergei A. Kharitonov, Peter J. Barnes,