CCL18 in serum, BAL fluid and alveolar macrophage culture supernatant inÂ interstitial lung diseases

Article ID	Journal	Published Year	Pages	File Type
6242459	Respiratory Medicine	2013	9 Pages	PDF

Abstract

CCL18 levels in serum, BALF and AM culture supernatant are markedly increased in various inflammatory and fibrotic ILDs. However, the CCL18 level being highest in HP among the investigated ILDs suggests that CCL18 may be more profoundly involved in inflammatory immune responses.

Keywords

RB-ILD PARC NSIP HRCT T-helper Sao2 IIP DLCO CCL AMAC TNF DIP ATS/ERS CCL18 IPF LPS MIP COP American Thoracic Society/European Respiratory Society ILD inflammation interferon IFN interleukin BALF Interstitial lung disease Enzyme-linked immunosorbent assay ELISA high-resolution computed tomography Forced expiratory volume diffusing capacity of the lung for carbon monoxide Vital capacity tumor necrosis factor Fev idiopathic pulmonary fibrosis Fibrosis lipopolysaccharide CC chemokine ligand Alveolar macrophage Bronchoalveolar lavage fluid non-specific interstitial pneumonia Idiopathic interstitial pneumonia Desquamative interstitial pneumonia Cryptogenic organizing pneumonia Hypersensitivity pneumonitis