Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6246253 | Transplantation Proceedings | 2014 | 4 Pages |
Abstract
The kidney function of patients recovered to normal in both the EC-MPS and MMF groups. The mean concentration to peak (Cmax), the mean half-life (t1/2), and the area under the concentration-time curve (AUC0-12) of MPA in the EC-MPS group were higher than those in the MMF group (PÂ < .05). This indicated that the pharmacokinetic parameters for MPA when EC-MPS is co-administered with a PPI in kidney transplant patients in China is better than for comedication with MMF and a PPI. The MMF group had a higher incidence of drug withdrawal because of higher infection rates, leucocyte decrease, and more gastrointestinal side effects than the EC-MPS group (PÂ < .05). No significant differences in the clinical effect on kidney transplant recipients were observed in the limited observation time.
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Authors
L. Xu, M. Cai, B.-Y. Shi, Z.-L. Li, X. Li, H.-L. Jin,