Emerging Trends in TransplantationThoracic transplantationBody Mass Index in Lung Transplant Candidates: A Contra-indication to Transplant or Not?

BackgroundAccording to International Society of Heart and Lung Transplantation criteria, high body mass index (BMI; ≥30 kg/m2) is a relative contraindication for lung transplantation (LT). On the other hand, low BMI may be associated with worse outcome. We investigated the influence of pre-LT BMI on survival after LT in a single-center study.MethodsPatients were divided according to the World Health Organization criteria into 4 groups: BMI <18.5 kg/m2 (underweight), BMI 18.5-24.9 kg/m2 (normal weight), BMI 25-29.9 kg/m2 (overweight), and BMI ≥30 kg/m2 (obesity). An additional analysis was made per underlying disease.ResultsBMI was determined in a cohort of 546 LT recipients, of which 28% had BMI <18.5 kg/m2. Underweight resulted in similar survival (P = .28) compared with the normal weight group. Significantly higher mortality was found in overweight (P = .016) and obese patients (P = .031) compared with the normal-weight group. Subanalysis of either underweight (P = .19) or obese COPD patients (P = .50) did not reveal worse survival. In patients with interstitial lung disease, obesity was associated with increased mortality (P = .031) compared with the normal-weight group. In cystic fibrosis patients, underweight was not associated with a higher mortality rate (P = .12) compared with the normal-weight group.ConclusionsLow pre-LT BMI did not influence survival rate in our cohort, independently from underlying disease.