Functional Tumor Necrosis Factor Alpha Polymorphisms and Haplotype Analysis in High-Risk Corneal Transplantation

According to haplotype frequencies, our results suggest that the TCTGGA haplotype may confer additional protection against risk of immunological rejection whereas TCTAGA may increase risk of corneal allograft rejection in the high-risk setting. However, both haplotypes were relatively rare and thus would not warrant genotyping for individual patient selection for anti-TNF therapy.