Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6248807 | Transplantation Proceedings | 2006 | 5 Pages |
Abstract
Hepatocytes can be transfected with p3MTChins to produce human insulin but may lack the proper glucose-sensing or complex storage and secretion capabilities that allow for a finely tuned dynamic insulin response. Treatment is subtherapeutic, and p3MTChins-hepatocyte function may not endure in an autoimmune model. Without successful preliminary findings, cell therapy involving electroporation of p3MTChins does not appear to be practical as a therapy for diabetes and may not be a strategy to pursue at this time.
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Authors
R.H. Lee, G. Roll, V. Nguyen, H. Willenbring, Q. Tang, S.-M. Kang, P.G. Stock,