Case reportRegional skin invasion by glioblastoma multiforme

Glioblastoma multiforme is the most common and aggressive primary malignant brain tumor and usually invades the intracranial space. Extracranial invasion is uncommon, and skin invasions are even less common. Here, we present an extremely rare case of aggressive skin invasion by glioblastoma multiforme. Once skin invasion occurs, its spread is too rapid to be resectable in only a few weeks and is often accompanied by deterioration of the primary lesion and short-term survival. Recognizing small cutaneous tumors adjacent to a previous surgical site is vital at the initial stage of skin invasion. Early recognition of cutaneous lesions, resection, and pathological confirmation, followed by chemotherapy and radiotherapy, may be beneficial for these patients.