Short communicationAdenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent

•We studied pilocarpine-induced tremulous jaw movements in GPR37 knockout mouse.•Tremor inhibition by adenosine and muscarinic receptor antagonists was evaluated.•Parkinson's disease-associated GPR37 receptor deletion reduced tremor.•The adenosine A2A receptor antagonist-mediated tremor inhibition is GPR37-dependent.

GPR37, also known as parkin associated endothelin-like receptor (Pael-R), is an orphan GPCR that aggregates intracellularly in a juvenile form of Parkinson's disease. However, little is known about the function of this orphan receptor. Here, using a model for parkisonian tremor, the pilocarpine-induced tremulous jaw movements (TJMs), we show that the deletion of GPR37 attenuated the TJMs in response to this cholinomimetic. Interestingly, the control that adenosine A2A receptor exerted over TJMs was lost in the absence of GPR37, thus pointing to a pivotal role of this orphan receptor in the adenosinergic control of parkinsonian tremor.