Article ID Journal Published Year Pages File Type
6258718 Behavioural Brain Research 2013 5 Pages PDF
Abstract

•Tetramethylpyrazine protects scopolamine induced memory deficits.•Tetramethylpyrazine reverses scopolamine induced synaptic proteins loss.•Tetramethylpyrazine preserves the disruption of cAMP/PKA/CREB signal pathway.

Tetramethylpyrazine is used in the treatment of many neurological diseases because of its neuroprotective effect. Here, we demonstrate that administration of tetramethylpyrazine effectively reverses memory deficits induced by scopolamine. Moreover, tetramethylpyrazine preserves postsynaptic protein synthesis and restores cAMP/PKA/CREB pathway signaling deficits. Our study not only explores the actions of tetramethylpyrazine on synapses, but also provides novel evidence for the possible therapeutic use of tetramethylpyrazine in dementia.

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Life Sciences Neuroscience Behavioral Neuroscience
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