| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6259394 | Behavioural Brain Research | 2013 | 4 Pages |
Abstract
Orexins are important regulators of sleep-wakefulness (S-W). Rats were intracerebroventricularly (ICV)2 administered selective orexin-2 receptor antagonist, TCS-OX2-293. There was decreased wakefulness due to a decrease in the average wake episode duration and an increased REM sleep4 due to an increase in the number of REM episodes, indicating an inhibitory role of the central orexin-2 receptors on REM sleep generation.
⺠ICV injection of OX2R antagonist increased total sleep time and REM sleep. ⺠Increase in REM sleep was due to an increase in the number of REM episodes. ⺠Decrease in wakefulness was due to a decrease in the duration of wake episodes. ⺠Central OX2Rs exert an inhibitory control on REM sleep generation.
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Authors
Basheer Ahamad Kummangal, Deependra Kumar, Hruda Nanda Mallick,