Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6260102 | Behavioural Brain Research | 2010 | 5 Pages |
Abstract
The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.
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Authors
Amy. R. Wolff, David. K. Bilkey,