| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6260168 | Behavioural Brain Research | 2009 | 4 Pages |
Abstract
In the present study, the effects of intra-locus coeruleus (LC) injection of GABAB receptor-interacting agents on naloxone-induced withdrawal signs of morphine-dependent rats were examined. The GABAB receptor agonist and antagonists were injected 5Â min prior to naloxone injection. Baclofen, a GABAB receptor agonist, decreased the TWS in a dose-dependent manner but CGP35348, a GABAB receptor antagonist, alone had no effect. On the other hand, baclofen effects were reversed by CGP35348. It may be concluded that activation of GABAB receptor mechanisms in the LC reduces precipitated withdrawal symptoms from chronic morphine treatment.
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Authors
Esmail Riahi, Iraj Mirzaii-Dizgah, Seyed Morteza Karimian, Hamid Reza Sadeghipour Roodsari, Ahmad Reza Dehpour,