| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6262091 | Brain Research Bulletin | 2012 | 4 Pages |
The aim of present study is to clarify the role of apelin in regulating energy homeostasis in brown adipose tissue (BAT). We examined the central effects of apelin-13 on the brain c-fos like immunoreactivity (c-FLI), BAT temperature and the activity of the sympathetic nerve activity innervating BAT in rats. In the hypothalamus, central infusion into the third cerebral ventricle (i3vt) of apelin-13 caused induction of c-FLI in the paraventricular nucleus (PVN) compared with the controls (PBS-treated) group. In addition, microinjection of apelin-13 into the PVN produced significant increases in BAT temperature. Furthermore, microinjection of apelin-13 treatment increased BAT sympathetic nerve activity compared with controls.We conclude that apelin-13 microinjection into PVN increases sympathetic nerve activity innervating BAT.
⺠Central infusion of apelin-13 caused induction of c-fos in the paraventricular nucleus (PVN). ⺠Microinjection of apelin-13 into the PVN produced increases in brown adipose tissue (BAT) temperature. ⺠Microinjection of apelin-13 treatment increased BAT uncoupling protein 1 expression and sympathetic nerve activity.
