Research ReportRadial glial cells organize the central nervous system via microtubule dependant processes

•Radial glial cells orchestrate much of the formation of the CNS.•Their functions and morphology are dependent on microtubule arrangements.•Radial glial cell interkinetic nuclear migration is driven by kinesin and dynein.•Radial glial microtubule biogenesis disorders lead to lissencephaly type diseases.

The correct cytokinesis and polarization of radial glial cells are essential for populating and patterning the central nervous system. The microtubule (MT) cytoskeleton is central to regulating glial and neuronal functions during development and in the adult, providing the dynamic ability to extend processes, migrate, establish synaptic connections and transmit information. MT biogenesis disorders result in a spectrum of neurological deficits resulting from abnormal neuronal proliferation, migration and aberrant white matter formation. In the present review, we place a spotlight on the roles MTs play in orchestrating radial glial cell activities during interkinetic nuclear migration and neuronal translocation to cortical destinations along pia-directed processes. We also outline the consequences of MT dysfunction in the polarization and establishment of the radial glial cell scaffold.