Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6262943 | Brain Research | 2015 | 8 Pages |
â¢Hippocampal IGF2 injection within 9 h after training enhances memory consolidation.â¢Hippocampal IGF2 injection at 12 h after training enhances memory persistence.â¢Hippocampal IGF2 regulates memory consolidation or persistence via IGF2 receptor.
Memory consolidation is an important process for the formation of long-term memory. We have previously reported that mature brain-derived neurotrophic factor enhances memory consolidation within 9Â h after initial learning. Recent studies suggest that insulin-like growth factor 2 (IGF2) significantly enhances memory consolidation and prevents forgetting. Thus, we hypothesized that IGF2 exerts its activity on cognitive performance in a time-dependent manner as observed in our previous study. In the one-trial step-through inhibitory avoidance task, we demonstrate that a bilateral injection of IGF2 into the dorsal hippocampus 6 or 9Â h after training significantly enhanced the step-through latencies compared with the vehicle-treated controls in the retention trial, which was conducted 24Â h after the acquisition trial. However, 12Â h post-training, IGF2 injection did not increase the step-through latencies. Intriguingly, in the retention trial at 21 days after the training, hippocampal IGF2 injection 6, 9 or 12Â h after the acquisition trial significantly increased the step-through latencies compared with the vehicle-treated controls. IGF2 administration at 9Â h and 12Â h after the acquisition trial significantly increased discrimination index and exploration time on the novel-located object in the test trial at 24Â h and 21 days, respectively, after the acquisition trial in the novel location recognition task. In addition, IGF2-induced an increase in the step-through latencies in the retention trial 24Â h or 21 days, respectively, after the initial learning was completely abolished by co-injected anti-IGF2 receptor antibody. These results suggest that IGF2 enhances memory consolidation within 9Â h after initial learning, and increased IGF2 within the 12Â h after the acquisition trial, which represents a delayed consolidation phase, is also critical for memory persistence.