Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6263273 | Brain Research | 2014 | 8 Pages |
Abstract
Persistent effects of pre- and postischemic exercise on glial cells activation after global cerebral ischemia remains poorly understood. Here, we investigated the effect of both pre and postischemic treadmill exercise protocols (20Â min/day during 2 weeks) on glial cells immunostaining in the hippocampus of Wistar rats submitted to global ischemia. A synergistic effect between ischemia and postischemic exercise on the astrocytic area was demonstrated. Postischemic exercise partially reversed the ischemia-induced increase on the area occupied by microglia, without any effect of pre-ischemic protocol. In conclusion, postischemic exercise distinctly modulates astrocyte and microglia immunostaining in the hippocampal dentate gyrus following global cerebral ischemia in Wistar rats.
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Authors
Gisele Agustini Lovatel, Karine Bertoldi, Viviane Rostirola Elsnerb, Francele Valente Piazza, Carla Giovana Basso, Felipe dos Santos Moysés, Paulo Valdeci Worm, Carlos Alexandre Netto, Simone Marcuzzo, Ionara Rodrigues Siqueira,