Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6263764 | Brain Research | 2013 | 8 Pages |
â¢Influence of exercise on long-term memory and expression of synaptic proteins.â¢Exercise attenuated the long-term memory deficit induced by sleep deprivation.â¢Sleep deprivation does not alter hippocampal expression of synaptic proteins.â¢Treadmill exercise increases hippocampal expression of GAP-43.
The deleterious effects of paradoxical sleep deprivation (SD) on memory processes are well documented. Physical exercise improves many aspects of brain functions and induces neuroprotection. In the present study, we investigated the influence of 4 weeks of treadmill aerobic exercise on both long-term memory and the expression of synaptic proteins (GAP-43, synapsin I, synaptophysin, and PSD-95) in normal and sleep-deprived rats. Adult Wistar rats were subjected to 4 weeks of treadmill exercise training for 35Â min, five times per week. Twenty-four hours after the last exercise session, the rats were sleep-deprived for 96Â h using the modified multiple platform method. To assess memory after SD, all animals underwent training for the inhibitory avoidance task and were tested 24Â h later. The aerobic exercise attenuated the long-term memory deficit induced by 96Â h of paradoxical SD. Western blot analysis of the hippocampus revealed increased levels of GAP-43 in exercised rats. However, the expression of synapsin I, synaptophysin, and PSD-95 was not modified by either exercise or SD. Our results suggest that an aerobic exercise program can attenuate the deleterious effects of SD on long-term memory and that this effect is not directly related to changes in the expression of the pre- and post-synaptic proteins analyzed in the study.