Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6263908 | Brain Research | 2013 | 9 Pages |
The present work was aimed to study the protective effect of l-theanine on chronic restraint stress (CRS)-induced cognitive impairments in mice. The stress was produced by restraining the animals in well-ventilated polypropylene tubes (3.2Â cm in diameter Ã10.5Â cm in length) for 8Â h once daily for 21 consecutive days. L-theanine (2 and 4Â mg/kg) was administered 30Â min before the animals subjected to acute immobilized stress. At week 4, mice were subjected to Morris water maze and step-through tests to measure the cognitive function followed by oxidative parameters and corticosterone as well as catecholamines (norepinephrine and dopamine) subsequently. Our results showed that the cognitive performances in CRS group were markedly deteriorated, accompanied by noticeable alterations in oxidative parameters and catecholamine levels in the hippocampus and the cerebral cortex as well as corticosterone and catecholamine levels in the serum. However, not only did l-theanine treatment exhibit a reversal of the cognitive impairments and oxidative damage induced by CRS, but also reversed the abnormal level of corticosterone in the serum as well as the abnormal levels of catecholamines in the brain and the serum. This study indicated the protective effect of l-theanine against CRS-induced cognitive impairments in mice.
⺠Chronic restraint stress impaired cognitive function in adult mice. ⺠MWM and S-T tests showed that luteolin improved learning and memory of CRS mice. ⺠l-theanine normalized the levels of corticosterone and catecholamines in the serum. ⺠l-theanine reduced oxidative stress in the brain. ⺠l-theanine can be of therapeutic value for CRS-induced cognitive impairments.